Acetone → Solifenacin Succinate

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

Acetone (260 ml), Succinic acid (12.7 g, 0.107 mol) and water (5 ml) are combined in a flask. The mixture is heated under reflux until total dissolution and then kept at 42° C. Then, the “Solution of solifenacin base” is charged and the mixture is heated to reflux and kept under reflux for 15 minutes. The content is distilled until a final volume of 260 ml. The mixture is cooled slowly until a final temperature of 3° C. and then filtered. The residue is washed with Ethyl acetate (50 ml) at 0/5° C. and is drained for 1 hour. The wet cake is dried in the vacuum oven at 60° C. to give a white solid.

Herkunft & Nachweise