(S)-3-(Benzyl((S)-1-phenylethyl)amino)heptan-1-ol → (S)-3-aminoheptan-1-ol

HRID 1617138Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1617138
C([N:8]([C@H](C1C=CC=CC=1)C)[C@@H:9]([CH2:13][CH2:14][CH2:15][CH3:16])[CH2:10][CH2:11][OH:12])C1C=CC=CC=1>CCO.[Pd]>[NH2:8][C@@H:9]([CH2:13][CH2:14][CH2:15][CH3:16])[CH2:10][CH2:11][OH:12]

Komponenten

4

Edukt 1

HCID 68752972(S)-3-(Benzyl((S)-1-phenylethyl)amino)heptan-1-ol

Produkt 1

HCID 55290391(S)-3-aminoheptan-1-olAusbeute 89,3 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysator2×HCID 702EthanolLösungsmittel

Versuchsvorschrift

A solution of the product from step (iv) (5 g) and 5% Pd/C (0.5 g) in EtOH (25 mL) was hydrogenated under 5 bar at rt for 5 days. A further portion of 5% Pd/C (1.5 g) was added, and the reaction mixture hydrogenated under 5 bar at rt for a further 1 day. The reaction mixture was filtered and the solvent evaporated to give the subtitle compound 1.8 g.

Aufarbeitung

  1. filtrationThe reaction mixture was filtered
  2. customthe solvent evaporated

Quellen und Nachweise

ORD-Eintrag
ord-58baea65f88c45b4bd5a90fa37910cab
Quelldatensatz
uspto-grants-2014_07
Patentnummer
US08765939B2

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