Potassium Cyanide → 2-(4-((2-Amino-4-chloro-6-methylpyrimidin-5-yl)methyl)-3-methoxyphenyl)acetonitrile

HRID 1617173

Reaktionsgleichung

Reaktionsgleichung von HRID 1617173
[C-:1]#[N:2].[K+].[Cl:4][C:5]1[C:10]([CH2:11][C:12]2[CH:17]=[CH:16][C:15]([CH2:18]Cl)=[CH:14][C:13]=2[O:20][CH3:21])=[C:9]([CH3:22])[N:8]=[C:7]([NH2:23])[N:6]=1>CS(C)=O.CN(C=O)C.O>[NH2:23][C:7]1[N:6]=[C:5]([Cl:4])[C:10]([CH2:11][C:12]2[CH:17]=[CH:16][C:15]([CH2:18][C:1]#[N:2])=[CH:14][C:13]=2[O:20][CH3:21])=[C:9]([CH3:22])[N:8]=1

Komponenten

6

Edukt 2

HCID 9032Potassium CyanideHCID 866334014-Chloro-5-(4-(chloromethyl)-2-methoxybenzyl)-6-methylpyrimidin-2-amine

Produkt 1

HCID 866334022-(4-((2-Amino-4-chloro-6-methylpyrimidin-5-yl)methyl)-3-methoxyphenyl)acetonitrile

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 679Dimethyl SulfoxideLösungsmittelHCID 962WaterLösungsmittelHCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

Potassium cyanide (0.17 g) was added to a stirred solution of the product from step (ii) (0.40 g) in DMSO (5 mL) and DMF (5 mL). The mixture was stirred at rt for 15 h, diluted with water and then extracted with EtOAc. The combined organic phase was dried, filtered and evaporated to give the subtitle compound, 0.20 g.

Aufarbeitung

  1. extractionextracted with EtOAc
  2. customThe combined organic phase was dried
  3. filtrationfiltered
  4. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-7d13fb8c3de64bdaa52c665c53a1211a
Quelldatensatz
uspto-grants-2014_07
Patentnummer
US08765939B2

Verknüpfte Notizen

Wird geladen…