Butylamine → Methyl 4-((2-amino-4-(butylamino)-6-methylpyrimidin-5-yl)methyl)-3-methoxybenzoate

HRID 1617245

Reaktionsgleichung

Reaktionsgleichung von HRID 1617245
[NH2:1][C:2]1[N:7]=[C:6](Cl)[C:5]([CH2:9][C:10]2[CH:19]=[CH:18][C:13]([C:14]([O:16][CH3:17])=[O:15])=[CH:12][C:11]=2[O:20][CH3:21])=[C:4]([CH3:22])[N:3]=1.[CH2:23]([NH2:27])[CH2:24][CH2:25][CH3:26]>O1CCOCC1>[NH2:1][C:2]1[N:7]=[C:6]([NH:27][CH2:23][CH2:24][CH2:25][CH3:26])[C:5]([CH2:9][C:10]2[CH:19]=[CH:18][C:13]([C:14]([O:16][CH3:17])=[O:15])=[CH:12][C:11]=2[O:20][CH3:21])=[C:4]([CH3:22])[N:3]=1

Komponenten

4

Edukt 2

HCID 8007Butylamine2×HCID 86633398Methyl 4-((2-amino-4-chloro-6-methylpyrimidin-5-yl)methyl)-3-methoxybenzoate

Produkt 1

HCID 68413361Methyl 4-((2-amino-4-(butylamino)-6-methylpyrimidin-5-yl)methyl)-3-methoxybenzoate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Reaktionsbedingungen

Temperatur
90 °C

Versuchsvorschrift

A stirred mixture of the product from step (i) (8 g) and butylamine (7.40 ml) in dioxane (100 ml) was heated at 90° C. for 72 h. More butylamine (7.40 ml) was added and the reaction mixture stirred for a further 70 hrs. The solvent was evaporated and the crude product was purified by chromatography (5% MeOHiDCM) to afford the subtitle compound as a tan solid, 4.5 g.

Aufarbeitung

  1. customThe solvent was evaporated
  2. customthe crude product was purified by chromatography (5% MeOHiDCM)

Quellen und Nachweise

ORD-Eintrag
ord-0d8901fe8827401a852ac2672725dd85
Quelldatensatz
uspto-grants-2014_07
Patentnummer
US08765939B2

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