Hydroxyamine hydrochloride → 1-(2-Fluoro-5-methyl-pyridin-4-yl)-3,3-diphenyl-propan-1-one oxime
Reaktionsgleichung
[F:1][C:2]1[CH:7]=[C:6]([C:8](=O)[CH2:9][CH:10]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[C:5]([CH3:24])=[CH:4][N:3]=1.Cl.[NH2:26][OH:27].C([O-])(O)=O.[Na+]>>[F:1][C:2]1[CH:7]=[C:6]([C:8](=[N:26][OH:27])[CH2:9][CH:10]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[C:5]([CH3:24])=[CH:4][N:3]=1Komponenten
4
Versuchsvorschrift
In analogy to example 1, step 2, from 1-(2-fluoro-5-methyl-pyridin-4-yl)-3,3-diphenyl-propan-1-one and hydroxylamine hydrochloride in the presence of NaHCO3 was prepared the title compound as a mixture of E and Z isomers (1.5:1) as a white oil, MS (ESI+): m/z=335.1 ([M+H]+).