Hydroxyamine hydrochloride → 2-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)-1-pyridin-4-yl-ethanone oxime
Reaktionsgleichung
[CH:1]1[C:11]2[CH2:10][CH2:9][C:8]3[CH:12]=[CH:13][CH:14]=[CH:15][C:7]=3[CH:6]([CH2:16][C:17]([C:19]3[CH:24]=[CH:23][N:22]=[CH:21][CH:20]=3)=O)[C:5]=2[CH:4]=[CH:3][CH:2]=1.Cl.[NH2:26][OH:27].C([O-])(O)=O.[Na+]>>[CH:1]1[C:11]2[CH2:10][CH2:9][C:8]3[CH:12]=[CH:13][CH:14]=[CH:15][C:7]=3[CH:6]([CH2:16][C:17]([C:19]3[CH:24]=[CH:23][N:22]=[CH:21][CH:20]=3)=[N:26][OH:27])[C:5]=2[CH:4]=[CH:3][CH:2]=1Komponenten
4
Versuchsvorschrift
In analogy to example 1, step 2, from 2-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)-1-pyridin-4-yl-ethanone and hydroxylamine hydrochloride in the presence of NaHCO3 was prepared the title compound containing less than 5% of the Z-isomer as a white solid, MS (ESI+): m/z=([M+H]+).