Hydroxyamine hydrochloride → (R)-3-(4-Ethynyl-phenyl)-1-(2-methyl-pyridin-4-yl)-3-o-tolyl-propan-1-one oxime
Reaktionsgleichung
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([C@H:9]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=2[CH3:26])[CH2:10][C:11]([C:13]2[CH:18]=[CH:17][N:16]=[C:15]([CH3:19])[CH:14]=2)=O)=[CH:5][CH:4]=1)#[CH:2].Cl.[NH2:28][OH:29].C(=O)([O-])O.[Na+]>>[C:1]([C:3]1[CH:8]=[CH:7][C:6]([C@H:9]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=2[CH3:26])[CH2:10][C:11]([C:13]2[CH:18]=[CH:17][N:16]=[C:15]([CH3:19])[CH:14]=2)=[N:28][OH:29])=[CH:5][CH:4]=1)#[CH:2]Komponenten
4
Versuchsvorschrift
In analogy to example 132, step 6, from (R)-3-(4-ethynyl-phenyl)-1-(2-methyl-pyridin-4-yl)-3-o-tolyl-propan-1-one and hydroxylamine hydrochloride in the presence of sodium hydrogencarbonate was prepared the title compound as a white foam, MS (ESI+): m/z=355.4 ([M+H]+).