HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
N-bromobutanimide → 6-Bromo-7-hydroxychroman-2-one
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | N-bromobutanimide | HCID 67184 | — |
| Edukt | 7-Hydroxychromanone | HCID 298130 | — |
| Lösungsmittel | Acetonitrile | HCID 6342 | — |
| Produkt | 6-Bromo-7-hydroxychroman-2-one | HCID 46835416 | 54,9% |
Reaktionsschritte
A solution of Intermediate 1 (20 g) in acetonitrile (50 ml) was added with N-bromosuccinimide (20 g, WAKO) under ice cooling, and stirred for 10 minutes under ice cooling, and then stirred at room temperature for 1 hour. The reaction mixture was concentrated under reduced pressure, and then recrystallized from acetonitrile to obtain the title compound (15 g).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08772327B2 |
| Quelldatensatz | uspto-grants-2014_07 |
| ORD ID | ord-dc0c4128f5c74da9b017499c0d4ff735 |
| Quellennotiz | uspto-grants-2014_07 |