反应详情

A solution of Intermediate 1 (20 g) in acetonitrile (50 ml) was added with N-bromosuccinimide (20 g, WAKO) under ice cooling, and stirred for 10 minutes under ice cooling, and then stirred at room temperature for 1 hour. The reaction mixture was concentrated under reduced pressure, and then recrystallized from acetonitrile to obtain the title compound (15 g).

1. stirringstirred at room temperature for 1 hour
2. concentrationThe reaction mixture was concentrated under reduced pressure
3. customrecrystallized from acetonitrile