HCID 4183387, Verbindung → 5-Methyl-6-(4-morpholinyl)-3-pyridinamine

HRID 1620067Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1620067
[CH3:1][C:2]1[C:3]([N:11]2[CH2:16][CH2:15][O:14][CH2:13][CH2:12]2)=[N:4][CH:5]=[C:6]([N+:8]([O-])=O)[CH:7]=1>[Pd].CO>[CH3:1][C:2]1[CH:7]=[C:6]([NH2:8])[CH:5]=[N:4][C:3]=1[N:11]1[CH2:12][CH2:13][O:14][CH2:15][CH2:16]1

Komponenten

4

Edukt 1

HCID 4183387HCID 4183387, Verbindung

Produkt 1

HCID 592764965-Methyl-6-(4-morpholinyl)-3-pyridinamineAusbeute 90,3 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

A methanol (20 ml) solution containing 4-(3-methyl-5-nitropyridin-2-yl)morpholine (67 mg) was prepared and subjected to a hydrogenation reaction (room temperature; 1 bar; flow rate: 1 ml/min; 10% Pd/C) using H-cube™. Then, the solvent was distilled away under reduced pressure, and a purple solid of 5-methyl-6-morpholinopyridin-3-amine (52.4 mg) was thus obtained.

Aufarbeitung

  1. customwas prepared
  2. distillationThen, the solvent was distilled away under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-d83dde2cf9a84a209ad4766d0bdbbebe
Quelldatensatz
uspto-grants-2014_07
Patentnummer
US08772320B2

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