Sodium Bicarbonate → (1-{1-[2,4-Bis(trifluoromethyl)phenyl]ethyl}piperidin-4-yl)methanol

To a solution of (1-{1-[2,4-bis(trifluoromethyl)phenyl]ethenyl}piperidin-4-yl)methanol (12.6 g) in methanol (178 mL) was added sodium borohydride (2.02 g). The reaction mixture was stirred at room temperature for 20 min, saturated aqueous sodium hydrogen carbonate solution was added, and the mixture was extracted with ethyl acetate. The extract was washed with saturated brine, and dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (10.9 g).

1. extractionthe mixture was extracted with ethyl acetate
2. washThe extract was washed with saturated brine
3. dry with materialdried over anhydrous magnesium sulfate
4. customthe solvent was evaporated under reduced pressure
5. customThe residue was purified by silica gel column chromatography (ethyl acetate/hexane)

ORD-Eintrag

ord-08494a3b9f0d4416bf3d8b0e1a6044c9

Quelldatensatz

uspto-grants-2014_07

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US08772277B2