Maleic Acid → HCID 178456913, Verbindung
Reaktionsgleichung
[F:1][C:2]([F:31])([F:30])[C:3]1[CH:25]=[C:24]([C:26]([F:29])([F:28])[F:27])[CH:23]=[CH:22][C:4]=1[CH2:5][N:6]1[CH2:10][CH2:9][CH:8](/[CH:11]=[C:12]2/[C:13]([NH:18][CH2:19][C:20]#[CH:21])=[N:14][C:15](=[O:17])[S:16]/2)[CH2:7]1.[C:32]([OH:39])(=[O:38])/[CH:33]=[CH:34]\[C:35]([OH:37])=[O:36]>C(O)C>[C:32]([OH:39])(=[O:38])/[CH:33]=[CH:34]\[C:35]([OH:37])=[O:36].[F:31][C:2]([F:1])([F:30])[C:3]1[CH:25]=[C:24]([C:26]([F:28])([F:29])[F:27])[CH:23]=[CH:22][C:4]=1[CH2:5][N:6]1[CH2:10][CH2:9][CH:8](/[CH:11]=[C:12]2/[C:13]([NH:18][CH2:19][C:20]#[CH:21])=[N:14][C:15](=[O:17])[S:16]/2)[CH2:7]1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Reaktionsbedingungen
- Temperatur
- 80 °C
Versuchsvorschrift
To a solution of (5Z)-5-({1-[2,4-bis(trifluoromethyl)benzyl]pyrrolidin-3-yl}methylidene)-4-(prop-2-yn-1-ylamino)-1,3-thiazol-2(5H)-one (740 mg) in ethanol (10 mL) was added maleic acid (186 mg). The reaction mixture was stirred at 80° C. for 20 min, the solvent was evaporated under reduced pressure, and the residue was recrystallized from ethanol/heptane to give the title compound (800 mg).