Potassium hydroxy sulfite → 4-{[5-(Methylsulfinyl)-1,3-thiazol-2-yl]carbamoyl}phenyl acetate

HRID 1620886

Reaktionsgleichung

Reaktionsgleichung von HRID 1620886
[OH:1]OS([O-])=O.[K+].[C:7]([O:10][C:11]1[CH:16]=[CH:15][C:14]([C:17](=[O:26])[NH:18][C:19]2[S:20][C:21]([S:24][CH3:25])=[CH:22][N:23]=2)=[CH:13][CH:12]=1)(=[O:9])[CH3:8]>C(Cl)(Cl)Cl>[C:7]([O:10][C:11]1[CH:12]=[CH:13][C:14]([C:17](=[O:26])[NH:18][C:19]2[S:20][C:21]([S:24]([CH3:25])=[O:1])=[CH:22][N:23]=2)=[CH:15][CH:16]=1)(=[O:9])[CH3:8]

Komponenten

4

Edukt 2

HCID 23707502Potassium hydroxy sulfiteHCID 575718204-{[5-(Methylsulfanyl)-1,3-thiazol-2-yl]carbamoyl}phenyl acetate

Produkt 1

HCID 569693934-{[5-(Methylsulfinyl)-1,3-thiazol-2-yl]carbamoyl}phenyl acetate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel

Versuchsvorschrift

Using the Oxone® procedure as described in section 1.5.1.7 for the synthesis of compound (I), 515 (0.841 g, 2.73 mmol) gives crude 7. The crude product is stirred with chloroform (50 mL) and the suspension is filtered. The pad is washed once with chloroform and air dried to give pure 7 (0.35 g) as a white solid.

Aufarbeitung

  1. customgives crude 7
  2. filtrationthe suspension is filtered
  3. washThe pad is washed once with chloroform and air
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-7e3ee9d730574924bdaf720001ab6ccb
Quelldatensatz
uspto-grants-2014_07
Patentnummer
US08772502B2

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