Hydrochloric Acid → 7-Methyl-3,4-dihydropyrido[2,1-c][1,2,4]thiadiazine-9-carboxylic acid 2,2-dioxide

HRID 1622578

Reaktionsgleichung

Reaktionsgleichung von HRID 1622578
[CH3:1][C:2]1[CH:3]=[C:4]([C:14]([O:16]CC)=[O:15])[C:5]2[N:10]([CH:11]=1)[CH2:9][CH2:8][S:7](=[O:13])(=[O:12])[N:6]=2.[OH-].[Na+].Cl.O>CO>[CH3:1][C:2]1[CH:3]=[C:4]([C:14]([OH:16])=[O:15])[C:5]2[N:10]([CH:11]=1)[CH2:9][CH2:8][S:7](=[O:12])(=[O:13])[N:6]=2

Komponenten

6

Edukt 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 14798Sodium HydroxideHCID 66748581Ethyl 7-methyl-3,4-dihydropyrido[2,1-c][1,2,4]thiadiazine-9-carboxylate 2,2-dioxide

Produkt 1

HCID 667489647-Methyl-3,4-dihydropyrido[2,1-c][1,2,4]thiadiazine-9-carboxylic acid 2,2-dioxideAusbeute 83,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

To a solution of ethyl 7-methyl-3,4-dihydropyrido[2,1-c][1,2,4]thiadiazine-9-carboxylate 2,2-dioxide (106 mg) in methanol (1 mL) was added 1N aqueous sodium hydroxide solution (1 mL), and the mixture was stirred at room temperature for 1 hr. To the reaction mixture were added 1N hydrochloric acid (1.05 mL) and water (1 mL), and the resulting precipitate was collected by filtration, washed successively with water and a small amount of THF, and dried to give the title compound (79 mg) as a pale-yellow solid.

Aufarbeitung

  1. filtrationthe resulting precipitate was collected by filtration
  2. washwashed successively with water
  3. dry with materiala small amount of THF, and dried

Quellen und Nachweise

ORD-Eintrag
ord-8889c6c2a9b84074906708f3d9690ccc
Quelldatensatz
uspto-grants-2014_07
Patentnummer
US08778934B2

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