4-Toluenesulfonyl chloride → Methyl 2-hydroxy-5-{[(4-methylphenyl)sulfonyl]oxy}benzoate

HRID 1623656Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1623656
[OH:1][C:2]1[CH:11]=[CH:10][C:9]([OH:12])=[CH:8][C:3]=1[C:4]([O:6][CH3:7])=[O:5].C(=O)([O-])[O-].[K+].[K+].[S:19](Cl)([C:22]1[CH:28]=[CH:27][C:25]([CH3:26])=[CH:24][CH:23]=1)(=[O:21])=[O:20]>CC(C)=O>[OH:1][C:2]1[CH:11]=[CH:10][C:9]([O:12][S:19]([C:22]2[CH:28]=[CH:27][C:25]([CH3:26])=[CH:24][CH:23]=2)(=[O:21])=[O:20])=[CH:8][C:3]=1[C:4]([O:6][CH3:7])=[O:5]

Komponenten

5

Edukt 3

HCID 73974-Toluenesulfonyl chlorideHCID 11430Potassium CarbonateHCID 75077Methyl Gentisate

Produkt 1

HCID 15727852Methyl 2-hydroxy-5-{[(4-methylphenyl)sulfonyl]oxy}benzoate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

A mixture of methyl 2,5-dihydroxybenzoate (1.5 g, 8.92 mmol), potassium carbonate (7.50 g, 54.2 mmol), and dry acetone (100 ml) was stirred at room temperature for 30 min. To the mixture was added TsCl (1.72 g, 9.00 mmol) portionwise and the mixture was refluxed for 7 h. The reaction mixture was used in the next step directly.

Aufarbeitung

  1. temperaturethe mixture was refluxed for 7 h

Quellen und Nachweise

ORD-Eintrag
ord-84de467f8d274fb9b3a510b96ab648b3
Quelldatensatz
uspto-grants-2014_07
Patentnummer
US08778939B2

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