Dichloromethane → 1-(3,4-Difluorobenzyl)-2-oxo-1,2-dihydropyridine-3-carbonyl chloride

HRID 1625486Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1625486
[Cl:1]CCl.[F:4][C:5]1[CH:6]=[C:7]([CH:19]=[CH:20][C:21]=1[F:22])[CH2:8][N:9]1[CH:14]=[CH:13][CH:12]=[C:11]([C:15](O)=[O:16])[C:10]1=[O:18].C(Cl)(C(Cl)=O)=O>CN(C=O)C>[F:4][C:5]1[CH:6]=[C:7]([CH:19]=[CH:20][C:21]=1[F:22])[CH2:8][N:9]1[CH:14]=[CH:13][CH:12]=[C:11]([C:15]([Cl:1])=[O:16])[C:10]1=[O:18]

Komponenten

5

Edukt 3

HCID 6344DichloromethaneHCID 65578Oxalyl chlorideHCID 534279691-(3,4-Difluorobenzyl)-2-oxo-1,2-dihydropyridine-3-carboxylic acid

Produkt 1

HCID 593623351-(3,4-Difluorobenzyl)-2-oxo-1,2-dihydropyridine-3-carbonyl chloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

The flask was charged with dichloromethane, 20 mg of 1-(3,4-difluorobenzyl)-2-oxo-1,2-dihydropyridine-3-carboxylic acid, DMF, (COCl)2 was added slowly via syringe. Then the resulted mixture was allowed to stir at room temperature for 3 h. After TLC show the reaction was complete, the solvent was removed under high vacuum to give 25 mg of crude product, which was used for the next step reaction without further purification.

Aufarbeitung

  1. additionwas added slowly via syringe
  2. customthe solvent was removed under high vacuum

Quellen und Nachweise

ORD-Eintrag
ord-f43a7b016f0d4e24bf5199748fb79bbc
Quelldatensatz
uspto-grants-2014_07
Patentnummer
US08778977B2

Notizen zur Reaktion

Wird geladen…