Oxalyl chloride → 4-Ethylphenylacetyl chloride

HRID 1625853

Reaktionsgleichung

Reaktionsgleichung von HRID 1625853
[CH2:1]([C:3]1[CH:8]=[CH:7][C:6]([CH2:9][C:10]([OH:12])=O)=[CH:5][CH:4]=1)[CH3:2].C(Cl)(=O)C([Cl:16])=O>ClCCl.CN(C)C=O>[CH2:1]([C:3]1[CH:8]=[CH:7][C:6]([CH2:9][C:10]([Cl:16])=[O:12])=[CH:5][CH:4]=1)[CH3:2]

Komponenten

5

Edukt 2

HCID 65578Oxalyl chlorideHCID 84403(4-Ethylphenyl)acetic acid

Produkt 1

HCID 155783544-Ethylphenylacetyl chloride

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6228DimethylformamideKatalysatorHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

4-Ethylphenylacetic acid (3.0 g) (see Japanese Unexamined Patent Publication 63-233975) was dissolved in dichloromethane (15 ml), and thereto were added oxalyl chloride (6.0 ml) and N,N-dimethylformamide (one drop). The mixture was stirred at room temperature for 1.5 hours. The reaction mixture was evaporated under reduced pressure, and the residue was subjected to azeotropic distillation with toluene to give a crude 4-ethylphenylacetyl chloride, which was used in the subsequent step without further purification.

Aufarbeitung

  1. customThe reaction mixture was evaporated under reduced pressure
  2. distillationthe residue was subjected to azeotropic distillation with toluene

Quellen und Nachweise

ORD-Eintrag
ord-31eeafb1227e43058a73a4f990730905
Quelldatensatz
uspto-grants-2014_07
Patentnummer
US08785403B2

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