2,3-Dichloro-5,6-dicyano-1,4-benzoquinone → (9H-fluoren-9-yl)methyl 2-((3-(4-(2-hydroxypropan-2-yl)phenyl)-6-tosyl-6H-imidazo[1,5-a]pyrrolo[2,3-e]pyrazin-1-yl)methoxy)ethylcarbamate

HRID 1628101

Reaktionsgleichung

Reaktionsgleichung von HRID 1628101
COC1C=CC(C[O:8][C:9]([C:12]2[CH:17]=[CH:16][C:15]([C:18]3[N:19]=[C:20]([CH2:40][O:41][CH2:42][CH2:43][NH:44][C:45](=[O:61])[O:46][CH2:47][CH:48]4[C:60]5[CH:59]=[CH:58][CH:57]=[CH:56][C:55]=5[C:54]5[C:49]4=[CH:50][CH:51]=[CH:52][CH:53]=5)[N:21]4[C:26]5[CH:27]=[CH:28][N:29]([S:30]([C:33]6[CH:39]=[CH:38][C:36]([CH3:37])=[CH:35][CH:34]=6)(=[O:32])=[O:31])[C:25]=5[N:24]=[CH:23][C:22]=34)=[CH:14][CH:13]=2)([CH3:11])[CH3:10])=CC=1.COC1C=CC(COC(C2C=CC([Mg]Br)=CC=2)(C)C)=CC=1.C1C2C(COC(NCCOCC(O)=O)=O)C3C(=CC=CC=3)C=2C=CC=1.C(C1C(=O)C(Cl)=C(Cl)C(=O)C=1C#N)#N>C(Cl)Cl.FC(F)(F)C([O-])=O.[Hg+2].FC(F)(F)C([O-])=O.O>[OH:8][C:9]([C:12]1[CH:13]=[CH:14][C:15]([C:18]2[N:19]=[C:20]([CH2:40][O:41][CH2:42][CH2:43][NH:44][C:45](=[O:61])[O:46][CH2:47][CH:48]3[C:49]4[CH:50]=[CH:51][CH:52]=[CH:53][C:54]=4[C:55]4[C:60]3=[CH:59][CH:58]=[CH:57][CH:56]=4)[N:21]3[C:26]4[CH:27]=[CH:28][N:29]([S:30]([C:33]5[CH:34]=[CH:35][C:36]([CH3:37])=[CH:38][CH:39]=5)(=[O:32])=[O:31])[C:25]=4[N:24]=[CH:23][C:22]=23)=[CH:16][CH:17]=1)([CH3:10])[CH3:11]

Komponenten

8

Edukt 4

HCID 67752,3-Dichloro-5,6-dicyano-1,4-benzoquinoneHCID 455991832-(2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)ethoxy)acetic acidHCID 67362121(9H-fluoren-9-yl)methyl 2-((3-(4-(2-(4-methoxybenzyloxy)propan-2-yl)phenyl)-6-tosyl-6H-imidazo[1,5-a]pyrrolo[2,3-e]pyrazin-1-yl)methoxy)ethylcarbamateHCID 178491445HCID 178491445, Verbindung

Produkt 1

HCID 67216957(9H-fluoren-9-yl)methyl 2-((3-(4-(2-hydroxypropan-2-yl)phenyl)-6-tosyl-6H-imidazo[1,5-a]pyrrolo[2,3-e]pyrazin-1-yl)methoxy)ethylcarbamateAusbeute 45 %

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 2723924Mercury bis(trifluoroacetate)KatalysatorHCID 962WaterLösungsmittelHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a solution of (9H-fluoren-9-yl)methyl 2-((3-(4-(2-(4-methoxybenzyloxy)propan-2-yl)phenyl)-6-tosyl-6H-imidazo[1,5-a]pyrrolo[2,3-e]pyrazin-1-yl)methoxy)ethylcarbamate (0.077 g, 0.089 mmol, prepared using AF from Example #2, Step B cyano intermediate with ((4-(2-(4-methoxybenzyloxy)propan-2-yl)phenyl)magnesium bromide [NOVEL], AG, J.1 with 2-(2-(((9H-fluoren-9-yl)methoxy)carbonylamino)ethoxy)acetic acid [Chem Impex] and L.1 with mercury(II) trifluoroacetate) in DCM (0.94 mL) and Water (0.05 mL) was added DDQ (0.030 gg, 0.134 mmol). The mixture was stirred at rt for about 45 min. The mixture was directly purified by flash chromatography (12 g silica gel column, 35 to 100% EtOAc/heptane) to give (9H-fluoren-9-yl)methyl 2-((3-(4-(2-hydroxypropan-2-yl)phenyl)-6-tosyl-6H-imidazo[1,5-a]pyrrolo[2,3-e]pyrazin-1-yl)methoxy)ethylcarbamate (0.03 g, 45%): LC/MS (Table 2, Method b) Rt=2.90 min.; MS m/z: 742 (M+H)+.

Aufarbeitung

  1. customThe mixture was directly purified by flash chromatography (12 g silica gel column, 35 to 100% EtOAc/heptane)

Quellen und Nachweise

ORD-Eintrag
ord-5d002257b52e4a059c6d6de3211b1b80
Quelldatensatz
uspto-grants-2014_07
Patentnummer
US08785639B2

Verknüpfte Notizen

Wird geladen…