HCID 67497043, Verbindung → HCID 67496690, Verbindung

HRID 1628294Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1628294
[CH3:1][C:2]1[CH:7]=[C:6]([C:8]2[CH:9]=[C:10]([NH2:17])[CH:11]=[C:12]([N+:14]([O-])=O)[CH:13]=2)[CH:5]=[CH:4][N:3]=1>CO.[Pd]>[CH3:1][C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[C:12]([NH2:14])[CH:11]=[C:10]([NH2:17])[CH:9]=2)[CH:5]=[CH:4][N:3]=1

Komponenten

4

Edukt 1

HCID 67497043HCID 67497043, Verbindung

Produkt 1

HCID 67496690HCID 67496690, VerbindungAusbeute 91 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Reaktionsbedingungen

Temperatur
50 °C

Versuchsvorschrift

To a rt solution of 51.1B (1.10 mg, 4.8 mol) in MeOH (10 mL) was added 5% Pd/C. The heterogeneous solution was stirred at 50° C. under H2 for 4.0 hr. To the resulting mixture was added celite, solid was filtered off and washed with MeOH. The combined liquid was concentrated under reduced pressure to provide the title product 51.1C as colorless solid (865 mg, 91%).

Aufarbeitung

  1. additionTo the resulting mixture was added celite, solid
  2. filtrationwas filtered off
  3. washwashed with MeOH
  4. concentrationThe combined liquid was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-f742faefde4f4870a607373327a9c3ad
Quelldatensatz
uspto-grants-2014_07
Patentnummer
US08785468B2

Notizen zur Reaktion

Wird geladen…