Methyl 4-[(2,6-dinitrophenyl)amino]-3-hydroxybutanoate → Methyl 4-[(2,6-diaminophenyl)amino]-3-hydroxybutanoate

HRID 1628448Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1628448
[N+:1]([C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([N+:10]([O-])=O)[C:5]=1[NH:13][CH2:14][CH:15]([OH:21])[CH2:16][C:17]([O:19][CH3:20])=[O:18])([O-])=O>[Pd].O1CCCC1>[NH2:1][C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([NH2:10])[C:5]=1[NH:13][CH2:14][CH:15]([OH:21])[CH2:16][C:17]([O:19][CH3:20])=[O:18]

Komponenten

4

Edukt 1

HCID 86632868Methyl 4-[(2,6-dinitrophenyl)amino]-3-hydroxybutanoate

Produkt 1

HCID 68737495Methyl 4-[(2,6-diaminophenyl)amino]-3-hydroxybutanoateAusbeute 99 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

Under hydrogen gas atmosphere, a mixture of methyl 4-[(2,6-dinitrophenyl)amino]-3-hydroxybutanoate (Reference Example 79; 2.53 g, 8.45 mmol), 10% palladium on carbon (50% wet, 500 mg) and tetrahydrofuran (85 mL) was stirred at room temperature for 6 hr. The reaction mixture was filtered and concentrated in vacuo to give the title compound as a solid (2.00 g, 8.36 mmol, 99%).

Aufarbeitung

  1. filtrationThe reaction mixture was filtered
  2. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-fc8257e62e5f472cad901fece4160824
Quelldatensatz
uspto-grants-2014_07
Patentnummer
US08785460B2

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