HCID 86632904, Verbindung → HCID 68735949, Verbindung

HRID 1628541Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1628541
[F:1][C:2]1[CH:7]=[C:6]([N+:8]([O-])=O)[C:5]([NH:11][CH2:12][CH2:13][CH2:14][OH:15])=[C:4]([N+:16]([O-])=O)[CH:3]=1>O1CCCC1.[Pd]>[NH2:16][C:4]1[CH:3]=[C:2]([F:1])[CH:7]=[C:6]([NH2:8])[C:5]=1[NH:11][CH2:12][CH2:13][CH2:14][OH:15]

Komponenten

4

Edukt 1

HCID 86632904HCID 86632904, Verbindung

Produkt 1

HCID 68735949HCID 68735949, VerbindungAusbeute 100 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

A solution of 3-[(4-fluoro-2,6-dinitrophenyl)amino]propan-1-ol (3.59 g, 13.8 mmol) in tetrahydrofuran (140 mL) was stirred in the presence of 10% palladium on carbon (50% wet; 720 mg) under hydrogen atmosphere at room temperature for 1.5 h. The catalyst was removed by filtration, and the filtrate was concentrated in vacuo to give the title compound as a pale brown oil (2.75 g, 13.8 mmol, 100%).

Aufarbeitung

  1. customThe catalyst was removed by filtration
  2. concentrationthe filtrate was concentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-59fad46cda1c435b922b01194c2841d7
Quelldatensatz
uspto-grants-2014_07
Patentnummer
US08785460B2

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