Water → HCID 68773584, Verbindung

HRID 1628568Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1628568
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([NH2:8])[C:3]=1[NH:9][CH2:10][CH2:11][C:12]([O:14][CH2:15]C)=[O:13].Cl.[Cl:18][C:19]1[CH:24]=[C:23]([Cl:25])[CH:22]=[CH:21][C:20]=1[CH:26]([OH:31])[C:27](=N)OC.O>C(O)C>[NH2:8][C:4]1[C:3]2[N:9]([CH2:10][CH2:11][C:12]([O:14][CH3:15])=[O:13])[C:27]([CH:26]([C:20]3[CH:21]=[CH:22][C:23]([Cl:25])=[CH:24][C:19]=3[Cl:18])[OH:31])=[N:1][C:2]=2[CH:7]=[CH:6][CH:5]=1

Komponenten

5

Edukt 3

HCID 962WaterHCID 68736952HCID 68736952, VerbindungHCID 68737549HCID 68737549, Verbindung

Produkt 1

HCID 68773584HCID 68773584, VerbindungAusbeute 90,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

To a stirred solution of ethyl N-(2,6-diaminophenyl)-beta-alaninate (4.11 g, 18.4 mmol) in ethanol (36.8 mL) was added methyl 2-(2,4-dichlorophenyl)-2-hydroxyethanimidoate hydrochloride (5.59 g, 20.7 mmol) at room temperature. After 12 h, the reaction mixture was poured into water (120 mL). The resulting solid was collected by filtration and washed with ethyl acetate to afford the desired product as colorless solid (6.77 g, 16.6 mmol, 90%).

Aufarbeitung

  1. filtrationThe resulting solid was collected by filtration
  2. washwashed with ethyl acetate

Quellen und Nachweise

ORD-Eintrag
ord-89450b04da4243218089a57db0862ae2
Quelldatensatz
uspto-grants-2014_07
Patentnummer
US08785460B2

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