Water → FA amoxicillin

HRID 1629636

Reaktionsgleichung

Reaktionsgleichung von HRID 1629636
[CH3:1][C:2]1([CH3:25])[S:6][C@@H:5]2[C@H:7]([NH:10][C:11]([C@H:13]([NH2:21])[C:14]3[CH:15]=[CH:16][C:17]([OH:20])=[CH:18][CH:19]=3)=[O:12])[C:8](=[O:9])[N:4]2[C@H:3]1[C:22]([OH:24])=[O:23].O.C(N=C=NCCCN(C)C)C.[CH:38]1[C:43]([NH2:44])=[CH:42][C:41]2[C:45]([O:47][C:48]3([C:58]4[CH:59]=[CH:60][C:61]([OH:63])=[CH:62][C:57]=4[O:56][C:50]4[CH:51]=[C:52]([OH:55])[CH:53]=[CH:54][C:49]3=4)[C:40]=2[CH:39]=1)=[O:46]>C(#N)C>[CH:38]1[C:43]([NH2:44])=[CH:42][C:41]2[C:45]([O:47][C:48]3([C:58]4[CH:59]=[CH:60][C:61]([OH:63])=[CH:62][C:57]=4[O:56][C:50]4[CH:51]=[C:52]([OH:55])[CH:53]=[CH:54][C:49]3=4)[C:40]=2[CH:39]=1)=[O:46].[CH3:1][C:2]1([CH3:25])[S:6][C@@H:5]2[C@H:7]([NH:10][C:11]([C@H:13]([NH2:21])[C:14]3[CH:19]=[CH:18][C:17]([OH:20])=[CH:16][CH:15]=3)=[O:12])[C:8](=[O:9])[N:4]2[C@H:3]1[C:22]([OH:24])=[O:23]

Komponenten

6

Edukt 4

HCID 962WaterHCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 33613Amoxicillin2×HCID 768455-Aminofluorescein4×

Produkt 1

HCID 131731698FA amoxicillin

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

Fluoresceinamine (FA; 0.0583 g) was dissolved in 1.0 ml acetonitrile to from a FA solution. Amoxicillin (0.1 g) was dissolved in 30 ml deionized water, and mixed with the aforesaid FA solution. 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (0.0408 g) was added thereto and magnetically stirred at room temperature in the dark for 12 hours to make FA to graft to the carboxyl group of amoxicillin to form a fluorescent-labeled FA-amoxicillin. And, finally, the sample was freeze-dried to collect the fluorescent-labeled FA-amoxicillin.

Quellen und Nachweise

ORD-Eintrag
ord-adb1b15315a040e0ac32635795454c18
Quelldatensatz
uspto-grants-2014_07
Patentnummer
US08790695B2

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