Lithium Hydroxide → 3-(2-Chloroethoxy)propanoic acid

HRID 1629877

Reaktionsgleichung

Reaktionsgleichung von HRID 1629877
[Cl:1][CH2:2][CH2:3][O:4][CH2:5][CH2:6][C:7]([O:9]CC)=[O:8].[OH-].[Li+]>C(O)C>[Cl:1][CH2:2][CH2:3][O:4][CH2:5][CH2:6][C:7]([OH:9])=[O:8]

Komponenten

4

Edukt 2

HCID 3939Lithium HydroxideHCID 85848654Ethyl 3-(2-chloro-ethoxy)-propionate

Produkt 1

HCID 3436803-(2-Chloroethoxy)propanoic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

2.00 g (11.1 mmol) ethyl 3-(2-chloro-ethoxy)-propionate are suspended in 8 ml of ethanol and 4.96 ml (16.6 mmol) of 8% lithium hydroxide solution are added. The mixture is stirred for 4 hours at ambient temperature, then evaporated down i. vac., acidified with 2-molar hydrochloric acid, combined with diethyl ether and dried over sodium sulphate. Then it is filtered off and evaporated down i. vac.

Aufarbeitung

  1. customevaporated down i
  2. dry with materialdried over sodium sulphate
  3. filtrationThen it is filtered off
  4. customevaporated down i

Quellen und Nachweise

ORD-Eintrag
ord-91e653f6c9934104be09a854ffda7f38
Quelldatensatz
uspto-grants-2014_07
Patentnummer
US08791103B2

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