Methylamine → N-methyl-2-(3-hydroxy-2-oxo-1-pyrrolidinyl)acetamide

HRID 1632548Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1632548
[OH:1][CH:2]1[CH2:6][CH2:5][N:4]([CH2:7][C:8](OCC)=[O:9])[C:3]1=[O:13].[CH3:14][NH2:15]>O>[CH3:14][NH:15][C:8](=[O:9])[CH2:7][N:4]1[CH2:5][CH2:6][CH:2]([OH:1])[C:3]1=[O:13]

Komponenten

4

Edukt 2

HCID 6329MethylamineHCID 13385945ethyl (R/S)-2-(3-hydroxy-2oxo-1-pyrrolidinyl)acetate

Produkt 1

HCID 19817645N-methyl-2-(3-hydroxy-2-oxo-1-pyrrolidinyl)acetamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

1.0 g of ethyl (R/S)-2-(3-hydroxy-2-oxo-1-pyrrolidinyl)acetate is treated with 10 ml of a 40% solution of methylamine in water. After stirring at room temperature for 1 hour, the mixture is evaporated. The residue is shaken five times with acetonitrile in order to remove the water, whereupon in each case it is again evaporated. The residue is treated with diethyl ether. By filtration there is isolated N-methyl-2-(3-hydroxy-2-oxo-1-pyrrolidinyl)acetamide of melting point 129°-130.5°.

Aufarbeitung

  1. customthe mixture is evaporated
  2. stirringThe residue is shaken five times with acetonitrile in order
  3. customto remove the water, whereupon in each case it
  4. customis again evaporated
  5. additionThe residue is treated with diethyl ether
  6. filtrationBy filtration

Quellen und Nachweise

ORD-Eintrag
ord-a7e45fcab9e94107b251ed03599ac2b8
Quelldatensatz
uspto-grants-1984_10
Patentnummer
US04476308

Notizen zur Reaktion

Wird geladen…