Triethylamine → 1-(3,4,5-Trimethoxycinnamoyl)-4-[1-(ethylaminocarbonyl)ethyl]piperazine

HRID 1632966

Reaktionsgleichung

Reaktionsgleichung von HRID 1632966
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:11]=[C:12]([O:16][CH3:17])[C:13]=1[O:14][CH3:15])[CH:6]=[CH:7][C:8](Cl)=[O:9].C(N(CC)CC)C.[CH2:25]([NH:27][C:28]([CH:30]([N:32]1[CH2:37][CH2:36][NH:35][CH2:34][CH2:33]1)[CH3:31])=[O:29])[CH3:26]>C(Cl)(Cl)Cl>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:11]=[C:12]([O:16][CH3:17])[C:13]=1[O:14][CH3:15])[CH:6]=[CH:7][C:8]([N:35]1[CH2:34][CH2:33][N:32]([CH:30]([C:28]([NH:27][CH2:25][CH3:26])=[O:29])[CH3:31])[CH2:37][CH2:36]1)=[O:9]

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 1120942-Propenoyl chloride, 3-(3,4,5-trimethoxyphenyl)-, (2E)-HCID 13340427N-Ethyl-2-(piperazin-1-yl)propanamide

Produkt 1

HCID 543401181-(3,4,5-Trimethoxycinnamoyl)-4-[1-(ethylaminocarbonyl)ethyl]piperazine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel

Versuchsvorschrift

17.19 g of 3,4,5-trimethoxycinnamoyl chloride and 6.78 g of triethylamine are added with ice cooling to a solution of 9.54 g of 1-[1-(ethylaminocarbonyl)ethyl]piperazine in 200 ml of chloroform, and the resulting solution is kept standing at room temperature for 1 hour.

Quellen und Nachweise

ORD-Eintrag
ord-97c364da0c52479d931c09a58d290af7
Quelldatensatz
uspto-grants-1984_10
Patentnummer
US04478838

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