Hydrazine hydrate (1:1) → Endralazine

HRID 1633036Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1633036
[C:1]([N:9]1[CH2:19][CH2:18][C:12]2[N:13]=[N:14][C:15](Cl)=[CH:16][C:11]=2[CH2:10]1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.O.[NH2:21][NH2:22]>>[C:1]([N:9]1[CH2:19][CH2:18][C:12]2[N:13]=[N:14][C:15]([NH:21][NH2:22])=[CH:16][C:11]=2[CH2:10]1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Komponenten

3

Edukt 2

HCID 24654Hydrazine hydrate (1:1)HCID 12582765HCID 12582765, Verbindung

Produkt 1

HCID 47608Endralazine

Versuchsvorschrift

A suspension of 21.6 g of 6-benzoyl-3-chloro-5,6,7,8-tetrahydropyrido[4,3-c]pyridazine in 80 cc of hydrazine hydrate is boiled at reflux at an oil bath temperature of 110° for 1 hour. After a reaction time of approximately 15 minutes the material dissolves completely. The crude title compound resulting after cooling the mixture, is washed with a small amount of absolute ethanol and dissolved in 60 cc of dimethyl formamide. 60 cc of absolute ethanol are added to the solution, whereupon the title compound crystallizes.

Aufarbeitung

  1. temperatureat reflux at an oil bath temperature of 110° for 1 hour
  2. dissolutionAfter a reaction time of approximately 15 minutes the material dissolves completely

Quellen und Nachweise

ORD-Eintrag
ord-42ad74e2cb9f491db7485b14e38898e0
Quelldatensatz
uspto-grants-1984_10
Patentnummer
US04478837

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