Aniline → Methyl 6-(phenylamino)hexanoate

HRID 1633150Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1633150
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Br[CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][C:14]([O:16][CH3:17])=[O:15].O.O.O.C([O-])(=O)C.[Na+]>C(O)C>[CH3:17][O:16][C:14]([CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][NH:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)=[O:15]

Komponenten

5

Edukt 3

HCID 6115AnilineHCID 4170292Methyl 6-BromohexanoateHCID 23665404Sodium Acetate Trihydrate

Produkt 1

HCID 20441676Methyl 6-(phenylamino)hexanoate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

Aniline (2.79 g, 2.73 ml), 6.27 g of methyl 6-bromohexanoate and 12.24 g (0.09 mole) of sodium acetate trihydrate are heated at 80°-100° overnight in 15 ml of absolute ethanol. After cooling, the mixture is poured into 75 ml of ice-water and extracted with ether. The organic extract is washed with water, dried over magnesium sulfate and evaporated in vacuo to give N-(5-methoxycarbonylpentyl)aniline.

Aufarbeitung

  1. temperatureAfter cooling
  2. extractionextracted with ether
  3. extractionThe organic extract
  4. washis washed with water
  5. dry with materialdried over magnesium sulfate
  6. customevaporated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-3ac78de5eb604d259375d050c0e78e7f
Quelldatensatz
uspto-grants-1984_10
Patentnummer
US04478842

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