Hydrochloric Acid → N-nitroso-N-(5-methoxycarbonylpentyl)-aniline

HRID 1633151Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1633151
[N:1]([O-:3])=O.[Na+].[CH3:5][O:6][C:7]([CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][NH:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=[O:8].Cl>O>[N:1]([N:14]([CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][C:7]([O:6][CH3:5])=[O:8])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=[O:3]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 20441676Methyl 6-(phenylamino)hexanoateHCID 23668193Sodium Nitrite

Produkt 1

HCID 13362122N-nitroso-N-(5-methoxycarbonylpentyl)-aniline

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

A solution of 1.4 g of sodium nitrite in 5 ml of water is added dropwise at 0°-10° to a mixture of 4.42 g of N-(5-methoxycarbonylpentyl)-aniline, 2.9 ml of concentrated hydrochloric acid, and ice as needed to maintain the desired temperature. The mixture is then allowed to stir at ambient temperature for 1 hour and is then extracted with ether. The extract is washed with water, dried over magnesium sulfate, and evaporated in vacuo to give N-nitroso-N-(5-methoxycarbonylpentyl)-aniline as an oil.

Aufarbeitung

  1. temperatureto maintain the desired temperature
  2. extractionis then extracted with ether
  3. washThe extract is washed with water
  4. dry with materialdried over magnesium sulfate
  5. customevaporated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-13e73071e92d43899593294fa55b015d
Quelldatensatz
uspto-grants-1984_10
Patentnummer
US04478842

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