2,6-Difluorobenzoic acid → Benzamide, 2,6-difluoro-N-methyl-

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Reaktionsgleichung

[F:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]([F:11])[C:3]=1[C:4](O)=[O:5].[C:12](N1C=CN=C1)([N:14]1C=CN=C1)=O.Cl.CN.C(N(C(C)C)CC)(C)C>>[F:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]([F:11])[C:3]=1[C:4]([NH:14][CH3:12])=[O:5]

Komponenten

Edukt 4

HCID 97962,6-Difluorobenzoic acid

HCID 682631,1'-Carbonyldiimidazole

HCID 81531Diisopropylethylamine

HCID 6364545Methylamine hydrochloride

Produkt 1

HCID 4106176Benzamide, 2,6-difluoro-N-methyl-

Versuchsvorschrift

The title compound was prepared from 2,6-difluorobenzoic acid (10 g, 63.2 mmol), carbonyldiimidazole (10.26 g, 63.5 mmol), methylamine hydrochloride (4.27 g, 63.25 mmol) and diisopropylethyl amine according to the procedure used for example 84 (Step A) to give near quantitative yield of the title compound.

Quellen und Nachweise

ORD-Eintrag: ord-87903239bff844dfb6b9479969497e88
Quelldatensatz: uspto-grants-2003_01
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US06506901B2

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