Dimethoxymethane → 4-(Ethylthio)benzyl chloride

HRID 1635964

Reaktionsgleichung

Reaktionsgleichung von HRID 1635964
[Cl-:1].[Al+3].[Cl-].[Cl-].[CH3:5]OCOC.[CH2:10]([S:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[CH3:11]>ClCCCl>[CH2:10]([S:12][C:13]1[CH:18]=[CH:17][C:16]([CH2:5][Cl:1])=[CH:15][CH:14]=1)[CH3:11]

Komponenten

5

Edukt 3

HCID 8020DimethoxymethaneHCID 12144(Ethylthio)benzeneHCID 6451240Aluminum(III) Chloride

Produkt 1

HCID 186738584-(Ethylthio)benzyl chloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 111,2-DichloroethaneLösungsmittel

Reaktionsbedingungen

Temperatur
5 °C

Versuchsvorschrift

Aluminum chloride (2 g, 15 mmol) was suspended in 8 mL 1,2-dichloroethane and the solution was cooled to 5° C. Dimethoxymethane (0.69 mL, 7.8 mmol) over 10 min. Ethylphenylsulfide (0.88 mL, 6.5 mmol) was added and the mixture was warmed to rt. After 15 h ice water was added and the mixture was extracted with methylene chloride (3×). The combined organic fractions were dried over magnesium sulfate and concentrated. The crude material was used directly in the next step.

Aufarbeitung

  1. temperaturethe mixture was warmed to rt
  2. extractionthe mixture was extracted with methylene chloride (3×)
  3. dry with materialThe combined organic fractions were dried over magnesium sulfate
  4. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-28964c644ded4d8ebef150e94210722b
Quelldatensatz
uspto-grants-2003_01
Patentnummer
US06511994B2

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