HCID 86586541, Verbindung → HCID 10156794, Verbindung

HRID 1636065Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1636065
C([O:8][NH:9][C:10](=[O:35])[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][O:18][C:19]1[CH:34]=[CH:33][C:22]2[O:23][CH2:24][C:25]3[CH:32]=[CH:31][CH:30]=[CH:29][C:26]=3[C:27](=[O:28])[C:21]=2[CH:20]=1)C1C=CC=CC=1>CO.[Pd]>[OH:8][NH:9][C:10](=[O:35])[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][O:18][C:19]1[CH:34]=[CH:33][C:22]2[O:23][CH2:24][C:25]3[CH:32]=[CH:31][CH:30]=[CH:29][C:26]=3[C:27](=[O:28])[C:21]=2[CH:20]=1

Komponenten

4

Edukt 1

HCID 86586541HCID 86586541, Verbindung

Produkt 1

HCID 10156794HCID 10156794, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

400 mg (0.845 mmol) 8-(11-Oxo-6,11-dihydro-dibenzo[b,e]oxepin-2 yloxy)-octanoic acid benzyloxyamide in 50 ml methanol was hydrogenated in the presence of palladium on calcium carbonate at ambient temperature and pressure. The catalyst was removed by filtration and the solvent was evaporated. The residue was purified by column chromatography (methanol/water 75:25). There was thus obtained 90 mg (28%) of the title compound as an amorphous solid. MS: 382 (M−H+); 384 (M+H+).

Aufarbeitung

  1. customThe catalyst was removed by filtration
  2. customthe solvent was evaporated
  3. customThe residue was purified by column chromatography (methanol/water 75:25)

Quellen und Nachweise

ORD-Eintrag
ord-9450982f2fc1429b88f10c77f65d4f73
Quelldatensatz
uspto-grants-2003_01
Patentnummer
US06512123B2

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