Trityl chloride → Ethyl 1-trityl-1H-imidazole-4-carboxylate

HRID 1636813Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1636813
[NH:1]1[CH:5]=[C:4]([C:6]([O:8][CH2:9][CH3:10])=[O:7])[N:3]=[CH:2]1.C(N(CC)CC)C.[C:18](Cl)([C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1)([C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>C(Cl)(Cl)Cl>[C:18]([N:1]1[CH:5]=[C:4]([C:6]([O:8][CH2:9][CH3:10])=[O:7])[N:3]=[CH:2]1)([C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)([C:31]1[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=1)[C:25]1[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=1

Komponenten

5

Edukt 3

HCID 6456Trityl chlorideHCID 8471TriethylamineHCID 178469898HCID 178469898, Verbindung

Produkt 1

HCID 618225Ethyl 1-trityl-1H-imidazole-4-carboxylate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel

Versuchsvorschrift

A suspension of ethyl imidazole-4-carboxylate (1.4 g), triethylamine (1.2 g) and chloroform (20 ml) was stirred at room temperature while trityl chloride (3.06 g) was added, and the mixture was stirred at room temperature for 1 h. The resulting solution was washed with water, dried and evaporated to dryness under reduced pressure, and the residue was crystallised from a mixture of ethyl acetate and cyclohexane, to give ethyl 1-tritylimidazole-4-carboxylate, mp 163°-164°.

Aufarbeitung

  1. additionwas added
  2. washThe resulting solution was washed with water
  3. customdried
  4. customevaporated to dryness under reduced pressure
  5. customthe residue was crystallised from a mixture of ethyl acetate and cyclohexane

Quellen und Nachweise

ORD-Eintrag
ord-91ce51a165e840c2a0015a804d1ff624
Quelldatensatz
uspto-grants-2000_03
Patentnummer
USRE036617

Notizen zur Reaktion

Wird geladen…