2-(1,4-Dioxaspiro[4.5]dec-7-en-8-yl)pyridine → 2-(1,4-Dioxaspiro[4.5]decan-8-yl)pyridine

HRID 1637090Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1637090
[O:1]1[C:5]2([CH2:10][CH2:9][C:8]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][N:12]=3)=[CH:7][CH2:6]2)[O:4][CH2:3][CH2:2]1>C(OCC)(=O)C.[Pd]>[O:1]1[C:5]2([CH2:6][CH2:7][CH:8]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][N:12]=3)[CH2:9][CH2:10]2)[O:4][CH2:3][CH2:2]1

Komponenten

4

Edukt 1

HCID 211876502-(1,4-Dioxaspiro[4.5]dec-7-en-8-yl)pyridine

Produkt 1

HCID 211876632-(1,4-Dioxaspiro[4.5]decan-8-yl)pyridine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

To a solution of 14.6 g (67.19 mmol) of 2-(1,4-dioxaspiro[4.5]dec-7-en-8-yl)pyridine in ethyl acetate (400 mL) was added 4.6 g of 10% palladium on carbon catalyst. The resulting suspension was then hydrogenated at ambient temperature and atmospheric pressure until all the starting material was consumed (10.5 hr). The reaction mixture was filtered through celite and the filtrate was concentrated to give the product as an oily solid.

Aufarbeitung

  1. customwas then hydrogenated at ambient temperature
  2. customatmospheric pressure until all the starting material was consumed (10.5 hr)
  3. filtrationThe reaction mixture was filtered through celite
  4. concentrationthe filtrate was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-c47ff6e0b52f4cb4870799b9c9deb7e8
Quelldatensatz
uspto-grants-2000_03
Patentnummer
US06037354

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