3-Methoxypropyl 4-methylbenzenesulfonate → 3-[4-(3-Methoxypropoxy)-2-methoxyphenyl]heptanoic Acid

HRID 1637539Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1637539
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([CH2:14][CH2:15][CH2:16][CH3:17])[CH2:9][C:10]([O:12]C)=[O:11])=[C:4]([O:18][CH3:19])[CH:3]=1.[CH3:20][O:21][CH2:22][CH2:23][CH2:24]OS(C1C=CC(C)=CC=1)(=O)=O>CCOCC>[CH3:20][O:21][CH2:22][CH2:23][CH2:24][O:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([CH2:14][CH2:15][CH2:16][CH3:17])[CH2:9][C:10]([OH:12])=[O:11])=[C:4]([O:18][CH3:19])[CH:3]=1

Komponenten

4

Edukt 2

HCID 135229883-Methoxypropyl 4-methylbenzenesulfonateHCID 19348616Methyl 3-(4-hydroxy-2-methoxyphenyl)heptanoate

Produkt 1

HCID 193487163-[4-(3-Methoxypropoxy)-2-methoxyphenyl]heptanoic Acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

Following a similar procedure to that described in Preparation 45A(i), but using methyl 3-(4-hydroxy-2-methoxyphenyl)heptanoate (prepared as described in Preparation 58A), and 3-methoxy-1-tosyloxypropane, the corresponding ether derivative was obtained. Hydrolysis of this derivative and subsequent treatment of the reaction mixture were conducted in a similar manner to that described in Preparation 7 to give the title compound as an oily substance.

Aufarbeitung

  1. customthat described in Preparation 45A(i)
  2. customHydrolysis of this derivative and subsequent treatment of the reaction mixture
  3. customdescribed in Preparation 7

Quellen und Nachweise

ORD-Eintrag
ord-add7bf2443204833ab1e8db175d04258
Quelldatensatz
uspto-grants-2000_03
Patentnummer
US06040339

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