Water → Ethyl 2-(4-methoxybenzamido)-3-oxobutanoate

HRID 1638311Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1638311
Cl.[NH2:2][CH:3]([C:9](=[O:11])[CH3:10])[C:4]([O:6][CH2:7][CH3:8])=[O:5].C(N(CC)CC)C.[CH3:19][O:20][C:21]1[CH:29]=[CH:28][C:24]([C:25](Cl)=[O:26])=[CH:23][CH:22]=1.O>C(Cl)Cl>[CH3:19][O:20][C:21]1[CH:29]=[CH:28][C:24]([C:25]([NH:2][CH:3]([C:9](=[O:11])[CH3:10])[C:4]([O:6][CH2:7][CH3:8])=[O:5])=[O:26])=[CH:23][CH:22]=1

Komponenten

6

Edukt 4

HCID 962WaterHCID 7477p-Anisoyl chlorideHCID 8471TriethylamineHCID 13282897Ethyl 2-amino-3-oxobutanoate hydrochloride

Produkt 1

HCID 15623096Ethyl 2-(4-methoxybenzamido)-3-oxobutanoateAusbeute 83 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

Ethyl 2-amino-3-oxobutanoate hydrochloride (1 g) was suspended in dry methylene chloride (30 ml) and dissolution was effected with addition of triethylamine (1.69 ml). After adding 4-methoxybenzoyl chloride (0.91 ml) dropwise under cooling, the reaction mixture was allowed to warm up to room temperature and to react for 20 minutes. The mixture was treated with water and extracted with methylene chloride. The extract was washed with water, 1N-HCl, 4% aqueous sodium bicarbonate and saturated aqueous NaCl, dried (anhydrous Na2SO4) and concentrated. The residue was dissolved in developing solvent (benzene:ethyl acetate=4:1) and applied on a silica gel column. The first fraction (unpurities) was discarded and the following fraction was pooled and concentrated to give ethyl 2-(4-methoxybenzamido)-3-oxobutanoate (1.28 g, 83%) as white solid, m.p. 67°-69° C.

Aufarbeitung

  1. dissolutiondissolution
  2. temperatureunder cooling
  3. customto react for 20 minutes
  4. extractionextracted with methylene chloride
  5. washThe extract was washed with water, 1N-HCl, 4% aqueous sodium bicarbonate and saturated aqueous NaCl
  6. dry with materialdried (anhydrous Na2SO4)
  7. concentrationconcentrated
  8. dissolutionThe residue was dissolved
  9. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-6f7b2b0bb0a44d4aab9e461e9e5e43fe
Quelldatensatz
uspto-grants-1989_11
Patentnummer
US04879295

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