Kojic Acid → 5-(benzhydryloxy)-2-(hydroxymethyl)-4H-pyran-4-one
Reaktionsgleichung
[CH:1]1[C:6](=[O:7])[C:5]([OH:8])=[CH:4][O:3][C:2]=1[CH2:9][OH:10].[C:11]1([C:17]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[N+]=[N-])[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>C(O)C>[CH:17]([O:8][C:5]1[C:6](=[O:7])[CH:1]=[C:2]([CH2:9][OH:10])[O:3][CH:4]=1)([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Reaktionsbedingungen
- Temperatur
- 60 °C
Versuchsvorschrift
14.2 g (0.1 mol) of kojic acid was added to ethanol (400 ml), and heated to 60° C. and dissolved. After cooling the solution to room temperature, 29.1 g (0.15 mol) of diphenyldiazomethane was added thereto, and the mixture was reacted at room temperature for 18 hours under stirring. The reaction solution was concentrated to dryness, and benzene (300 ml) was added thereto. Then, insolubles were removed by filtration. To the filtrate, water (300 ml) was added, and the precipitates thereby formed were collected by filtration, and washed with benzene to obtain 17.5 g (yield: 56.8%) of the above identified compound.
Aufarbeitung
- dissolutiondissolved
- temperatureAfter cooling the solution to room temperature
- customthe mixture was reacted at room temperature for 18 hours
- concentrationThe reaction solution was concentrated to dryness, and benzene (300 ml)
- additionwas added
- customThen, insolubles were removed by filtration
- additionTo the filtrate, water (300 ml) was added
- customthe precipitates
- customthereby formed
- filtrationwere collected by filtration
- washwashed with benzene
- customto obtain 17.5 g (yield: 56.8%) of the
Quellen und Nachweise
- ORD-Eintrag
- ord-5b76433059b74213a1aa1ca94fa6bcda
- Quelldatensatz
- uspto-grants-1989_11
- Patentnummer
- US04883879
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