Nitric Acid → 7-nitro-5H-pyrrolo[2,3-b]pyrazine

HRID 1639578

Reaktionsgleichung

Reaktionsgleichung von HRID 1639578
[N:1]1[CH:6]=[CH:5][N:4]=[C:3]2[NH:7][CH:8]=[CH:9][C:2]=12.[N+:10]([O-])([OH:12])=[O:11].C(=O)(O)[O-].[Na+]>O>[N+:10]([C:9]1[C:2]2[C:3](=[N:4][CH:5]=[CH:6][N:1]=2)[NH:7][CH:8]=1)([O-:12])=[O:11]

Komponenten

5

Edukt 3

HCID 944Nitric AcidHCID 516892Sodium BicarbonateHCID 53708035H-Pyrrolo[2,3-b]pyrazine

Produkt 1

HCID 122071927-nitro-5H-pyrrolo[2,3-b]pyrazine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

7-Nitro-5H-pyrrolo[2,3-b]pyrazine (5) is prepared by adding 5H-pyrrolo[2,3-b]pyrazine (3) to fuming nitric acid while cooling (e.g. 0° C.). After stirring for one to several hours, water is carefully added and the mixture neutralized with saturated sodium bicarbonate. The solids are collected by filtration and dried to provide 7-nitro-5H-pyrrolo[2,3-b]pyrazine 5.

Aufarbeitung

  1. custom7-Nitro-5H-pyrrolo[2,3-b]pyrazine (5) is prepared
  2. additionis carefully added
  3. filtrationThe solids are collected by filtration
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-2f08133920194a08827817773bbfdaf3
Quelldatensatz
uspto-grants-2012_02
Patentnummer
US08110576B2

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