Acetohydroxamic Acid → 4-Methoxy-1,2-benzoxazol-3-amine

HRID 16396Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 16396
[C:1]([NH:4][OH:5])(=O)[CH3:2].CC(C)([O-])C.[K+].F[C:13]1[CH:20]=[CH:19]C=[C:17]([O:21][CH3:22])[C:14]=1C#N.[Cl-].[Na+].C[N:26](C)C=O>>[CH3:22][O:21][C:17]1[C:2]2[C:1]([NH2:26])=[N:4][O:5][C:19]=2[CH:20]=[CH:13][CH:14]=1

Komponenten

6

Edukt 5

HCID 1990Acetohydroxamic AcidHCID 5234Sodium ChlorideHCID 6228DimethylformamideHCID 5231012-Fluoro-6-methoxybenzonitrileHCID 23665647Potassium tert-butoxide

Produkt 1

HCID 27797514-Methoxy-1,2-benzoxazol-3-amine

Reaktionsbedingungen

Temperatur
60 °C

Versuchsvorschrift

709.5 mg (9.45 mmol) of acetohydroxamic acid are initially charged in 8 ml of anhydrous dimethylformamide, and 1.06 g (9.45 mmol) of potassium tert-butoxide are added at room temperature. After 40 minutes of stirring, 1 g (6.62 mmol) of 2-fluoro-6-methoxybenzonitrile is added. The mixture is heated at 60° C. for 16 hours. 20 ml of saturated sodium chloride solution are then added to the reaction mixture. The precipitated crystals are filtered off with suction and washed with water.

Aufarbeitung

  1. filtrationThe precipitated crystals are filtered off with suction
  2. washwashed with water

Quellen und Nachweise

ORD-Eintrag
ord-acb4e7ee3dec4c4ea677ed50342c344e
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07737153B2

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