HCID 58902472, Verbindung → Tert-butyl 4-{2-[2-amino-4-(trifluoromethyl)phenoxy]ethyl}piperazine-1-carboxylate

HRID 1640133Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1640133
[N+:1]([C:4]1[CH:25]=[C:24]([C:26]([F:29])([F:28])[F:27])[CH:23]=[CH:22][C:5]=1[O:6][CH2:7][CH2:8][N:9]1[CH2:14][CH2:13][N:12]([C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])[CH2:11][CH2:10]1)([O-])=O>[Pd].CCOC(C)=O>[NH2:1][C:4]1[CH:25]=[C:24]([C:26]([F:28])([F:29])[F:27])[CH:23]=[CH:22][C:5]=1[O:6][CH2:7][CH2:8][N:9]1[CH2:10][CH2:11][N:12]([C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])[CH2:13][CH2:14]1

Komponenten

4

Edukt 1

HCID 58902472HCID 58902472, Verbindung

Produkt 1

HCID 58902245Tert-butyl 4-{2-[2-amino-4-(trifluoromethyl)phenoxy]ethyl}piperazine-1-carboxylateAusbeute 72,2 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

Into a 1-neck round-bottom flask was added tert-butyl 4-{2-[2-nitro-4-(trifluoromethyl)phenoxy]ethyl}piperazine-1-carboxylate (2.44 g, 0.0058 mol), 5% palladium/carbon (0.20 g), and EtOAc (74 mL). The mixture was allowed to stir under an atmosphere of hydrogen overnight and then filtered through Celite. The filtrate was concentrated to give tert-butyl 4-{2-[2-amino-4-(trifluoromethyl)phenoxy]ethyl}piperazine-1-carboxylate (1.63 g, 68%) as a white solid. LCMS: (FA) ES+390.1.

Aufarbeitung

  1. filtrationfiltered through Celite
  2. concentrationThe filtrate was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-ccba84b88b5340cfb142bc6fdd9752c3
Quelldatensatz
uspto-grants-2012_02
Patentnummer
US08110687B2

Notizen zur Reaktion

Wird geladen…