4-(2-Fluoro-4-nitrophenoxy)-1-benzofuran → 4-(1-Benzofuran-4-yloxy)-3-fluorophenylamine

HRID 16410

Reaktionsgleichung

Reaktionsgleichung von HRID 16410
[F:1][C:2]1[CH:17]=[C:16]([N+:18]([O-])=O)[CH:15]=[CH:14][C:3]=1[O:4][C:5]1[C:10]2[CH:11]=[CH:12][O:13][C:9]=2[CH:8]=[CH:7][CH:6]=1>C(O)C.O1CCCC1.[Pt](=O)=O>[O:13]1[C:9]2[CH:8]=[CH:7][CH:6]=[C:5]([O:4][C:3]3[CH:14]=[CH:15][C:16]([NH2:18])=[CH:17][C:2]=3[F:1])[C:10]=2[CH:11]=[CH:12]1

Komponenten

4

Edukt 1

HCID 179793424-(2-Fluoro-4-nitrophenoxy)-1-benzofuran

Produkt 1

HCID 179793044-(1-Benzofuran-4-yloxy)-3-fluorophenylamine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 345198Adams' catalystKatalysatorHCID 21873804Tetrahydrofuran ethanolLösungsmittel

Versuchsvorschrift

Under argon, 150 mg (0.55 mmol) of 4-(2-fluoro-4-nitrophenoxy)-1-benzofuran (from example XXII) are initially charged in 5 ml of ethanol/tetrahydrofuran (1:1), platinum(IV) oxide is added and the mixture is hydrogenated under atmospheric pressure for 2 hours. The suspension is filtered off through CELITE (diatomaceous earth), the filtercake is washed with ethanol and the filtrate is concentrated using a rotary evaporator.

Aufarbeitung

  1. filtrationThe suspension is filtered off through CELITE (diatomaceous earth)
  2. washthe filtercake is washed with ethanol
  3. concentrationthe filtrate is concentrated
  4. customa rotary evaporator

Quellen und Nachweise

ORD-Eintrag
ord-e3cf80b818b84914a527d46ea5c07013
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07737153B2

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