Hydrochloric Acid → (1R,2S)-1-amino-2-methylindane hydrochloride

HRID 1641379Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1641379
[ClH:1].[CH3:2][C@H:3]1[CH2:11][C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C@@H:4]1[NH:12]C(=O)COC>C(O)C.O>[ClH:1].[NH2:12][C@H:4]1[C:5]2[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=2)[CH2:11][C@@H:3]1[CH3:2]

Komponenten

5

Edukt 2

HCID 313Hydrochloric AcidHCID 66739634N-[(1R,2S)-2-methyl-1-indanyl]-2-methoxyacetamide

Produkt 1

HCID 66739261(1R,2S)-1-amino-2-methylindane hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 702EthanolLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

Concentrated hydrochloric acid (8 ml) was added to a solution of N-[(1R,2S)-2-methyl-1-indanyl]-2-methoxyacetamide (5.9 g, 0.0269 mol) in ethanol and water, and the mixture heated for 12 hours at reflux. The solvent was evaporated and a small amount of ethyl acetate added. The undissolved solid was filtered off to give (1R,2S)-1-amino-2-methylindane hydrochloride (1.0 g) as a solid, chemical purity>95%.

Aufarbeitung

  1. temperaturethe mixture heated for 12 hours
  2. temperatureat reflux
  3. customThe solvent was evaporated
  4. additiona small amount of ethyl acetate added
  5. filtrationThe undissolved solid was filtered off

Quellen und Nachweise

ORD-Eintrag
ord-a361b52d3240489d809eb2c9b5bb01f2
Quelldatensatz
uspto-grants-2012_02
Patentnummer
US08114991B2

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