Ethambutol Hydrochloride → Ethambutol

HRID 1643530

Reaktionsgleichung

Reaktionsgleichung von HRID 1643530
[CH3:1][CH2:2][C@H:3]([NH:6][CH2:7][CH2:8][NH:9][C@H:10]([CH2:13][OH:14])[CH2:11][CH3:12])[CH2:4][OH:5].Cl.Cl>C(=O)([O-])[O-].[Na+].[Na+].[OH-].[Na+]>[CH3:12][CH2:11][C@H:10]([NH:9][CH2:8][CH2:7][NH:6][C@H:3]([CH2:4][OH:5])[CH2:2][CH3:1])[CH2:13][OH:14]

Komponenten

4

Edukt 1

HCID 14051Ethambutol Hydrochloride3×

Produkt 1

HCID 14052Ethambutol

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 10340Sodium CarbonateLösungsmittelHCID 14798Sodium HydroxideLösungsmittel

Versuchsvorschrift

Ethambutol Dihydrochloride (ETB) is obtained from MP Biomedicals (Aurora, Ohio). ETB (7 grams) are dissolved in 100 mL of a saturated solution of sodium carbonate in 5M NaOH. The solution is stirred for 10 minutes and the free based ETB is extracted with three volumes of chloroform. The solution is dried over sodium sulfate. After filtration, the chloroform is removed by rotary evaporation. Ethambutol is represented in the structure below (a).

Aufarbeitung

  1. extractionis extracted with three volumes of chloroform
  2. dry with materialThe solution is dried over sodium sulfate
  3. filtrationAfter filtration
  4. customthe chloroform is removed by rotary evaporation

Quellen und Nachweise

ORD-Eintrag
ord-bc6a8db3687a4cab96373542461f07a9
Quelldatensatz
uspto-grants-2012_02
Patentnummer
US08119840B2

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