4-Tert-butyl-2-nitrobenzoic acid → 2-Amino-4-tert-butylbenzoic acid
Reaktionsgleichung
[C:1]([C:5]1[CH:13]=[CH:12][C:8]([C:9]([OH:11])=[O:10])=[C:7]([N+:14]([O-])=O)[CH:6]=1)([CH3:4])([CH3:3])[CH3:2]>[Pd].C(O)C>[NH2:14][C:7]1[CH:6]=[C:5]([C:1]([CH3:4])([CH3:3])[CH3:2])[CH:13]=[CH:12][C:8]=1[C:9]([OH:11])=[O:10]Komponenten
4
Edukt 1
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 2
Versuchsvorschrift
4-tert-Butyl-2-nitro-benzoic acid (199 mg, 8.91 mmol), and 10% palladium on carbon (40 mg) were stirred in 6 mL ethanol under an atmosphere of hydrogen for 3 hours. The resulting mixture was filtered and concentrated in vacuo to yield 2-Amino-4-tert-butyl-benzoic acid (177 mg, 0.916 mmol).
Aufarbeitung
- filtrationThe resulting mixture was filtered
- concentrationconcentrated in vacuo
Quellen und Nachweise
- ORD-Eintrag
- ord-20209104b3e84dc8811a47142297453d
- Quelldatensatz
- uspto-grants-2012_02
- Patentnummer
- US08124604B2
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