Cl.[NH2:2][C:3]1[C:12]2[C:7](=[CH:8][C:9]([Cl:13])=[CH:10][CH:11]=2)[CH:6]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[N+:20]([O-])=O)[CH2:5][N:4]=1.CCCCCCC.N.Cl>C(OCC)(=O)C.O=[Pt]=O.CO.ClCCl>[ClH:13].[NH2:2][C:3]1[C:12]2[C:7](=[CH:8][C:9]([Cl:13])=[CH:10][CH:11]=2)[CH:6]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[NH2:20])[CH2:5][N:4]=1
was obtained in analogy to the method indicated in Example 1 g) from 1-amino-6-chloro-4-(2-nitrophenyl)-3,4-dihydroisoquinoline hydrochloride by hydrogenation with PtO2 and MPLC and an elution mixture of 10 parts by volume of ethyl acetate, 5 parts by volume of n-heptane, 5 parts by volume of dichloromethane, 5 parts by volume of methanol and 1 part by volume of concentrated aqueous ammonia solution. The product was dissolved in a little ethyl acetate, acidified with ethereal HCl, stirred at room temperature and filtered off with suction.
Wird geladen…
