Solketal → HCID 178431368, Verbindung

HRID 1645625

Reaktionsgleichung

Reaktionsgleichung von HRID 1645625
[Na:1].[CH3:2][C:3]1([CH3:31])[O:8]C[CH:6]([CH2:9][O:10][C:11]2[C:16](C)=[CH:15][N:14]=[C:13]([CH2:18][S:19]([C:21]3[NH:25][C:24]4[CH:26]=[CH:27][CH:28]=[CH:29][C:23]=4[N:22]=3)=[O:20])[C:12]=2[CH3:30])[CH2:5][O:4]1.CC1(C)OC(CO)CO1.ClC1C=C[N+]([O-])=C(C)C=1C.[F:51]C1C=CC2NC(S)=NC=2C=1>>[Na:1].[CH3:2][C:3]1([CH3:31])[O:8][CH:6]([CH2:9][O:10][C:11]2[CH:16]=[CH:15][N:14]=[C:13]([CH2:18][S:19]([C:21]3[NH:25][C:24]4[CH:26]=[CH:27][C:28]([F:51])=[CH:29][C:23]=4[N:22]=3)=[O:20])[C:12]=2[CH3:30])[CH2:5][O:4]1

Komponenten

5

Edukt 4

HCID 7528SolketalHCID 98774464-Chloro-2,3-dimethyl-1-oxidopyridin-1-iumHCID 667758472-(((4-((2,2-Dimethyl-1,3-dioxan-5-yl)methoxy)-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)-1h-benzimidazole sodium saltHCID 178505474HCID 178505474, Verbindung

Produkt 1

HCID 178431368HCID 178431368, VerbindungAusbeute 14,1 %

Versuchsvorschrift

The same procedure as in the step (10b) of Example 10 and the step (14b) of Example 14, the step (5f) of Example 5, the steps (11h) and (11i) of Example 11 was repeated using solketal, 4-chloro-2,3-dimethylpyridine 1-oxide, and 5-fluoro-1H-benzimidazole-2-thiol to obtain the title compound (210 mg, yield: 14.1%) as a white solid. Note that methanol was used as a solvent instead of ethanol in the same operation as in the step (5f).

Quellen und Nachweise

ORD-Eintrag
ord-ff6610614c054fd3bb2a3f0cc5d2356c
Quelldatensatz
uspto-grants-2012_02
Patentnummer
US08124780B2

Verknüpfte Notizen

Wird geladen…