N-(1-(2-(3,4-dimethoxyphenyl)ethyl)pyrrolidin-3-yl)phthalimide → 3-Amino-1-(2-(3,4-dimethoxyphenyl)ethyl)pyrrolidine

HRID 1645849

Reaktionsgleichung

Reaktionsgleichung von HRID 1645849
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:11][CH2:12][N:13]2[CH2:17][CH2:16][CH:15]([N:18]3C(=O)C4=CC=CC=C4C3=O)[CH2:14]2)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10]>C(O)C.O.NN>[NH2:18][CH:15]1[CH2:16][CH2:17][N:13]([CH2:12][CH2:11][C:5]2[CH:6]=[CH:7][C:8]([O:9][CH3:10])=[C:3]([O:2][CH3:1])[CH:4]=2)[CH2:14]1

Komponenten

4

Edukt 1

HCID 15045352N-(1-(2-(3,4-dimethoxyphenyl)ethyl)pyrrolidin-3-yl)phthalimide

Produkt 1

HCID 150453533-Amino-1-(2-(3,4-dimethoxyphenyl)ethyl)pyrrolidineAusbeute 100,3 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 702EthanolLösungsmittelHCID 24654Hydrazine hydrate (1:1)Lösungsmittel

Versuchsvorschrift

1.03 g of N-(1-(2-(3,4-dimethoxyphenyl)ethyl)pyrrolidin-3-yl)phthalimide was dissolved in 50 ml of ethanol, to which 2 ml of hydrazine monohydrate was added and refluxed under heating for 14 hours. The solvent was distilled off and an aqueous diluted solution of sodium hydroxide was added to the residue and extracted with chloroform. After drying with anhydrous magnesium sulfate, the solvent was distilled off, to obtain 0.68 g of the above-captioned compound (yield: 100%).

Aufarbeitung

  1. additionwas added
  2. temperaturerefluxed
  3. temperatureunder heating for 14 hours
  4. distillationThe solvent was distilled off
  5. additionan aqueous diluted solution of sodium hydroxide was added to the residue
  6. extractionextracted with chloroform
  7. dry with materialAfter drying with anhydrous magnesium sulfate
  8. distillationthe solvent was distilled off

Quellen und Nachweise

ORD-Eintrag
ord-7133ce3a17224f1e9223063767953259
Quelldatensatz
uspto-grants-1993_01
Patentnummer
US05177089

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