Hydrochloric Acid → HCID 19800070, Verbindung

HRID 1646881Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1646881
[ClH:1].[NH2:2][C:3]1[C:4]2[CH:14]=[CH:13][CH:12]=[CH:11][C:5]=2[S:6][C:7]=1[N+:8]([O-])=O>C(O)C.[Pd]>[ClH:1].[NH2:8][C:7]1[S:6][C:5]2[CH:11]=[CH:12][CH:13]=[CH:14][C:4]=2[C:3]=1[NH2:2]

Komponenten

5

Edukt 2

HCID 313Hydrochloric AcidHCID 32732623-Amino-2-nitro-benzo[b]thiophene

Produkt 1

HCID 19800070HCID 19800070, VerbindungAusbeute 101,5 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

Fuming hydrochloric acid (1.92 ml, 24 mmol) was added to a suspension of 3-amino-2-nitrobenzo[b]thiophene (4.66 g, 24 mmol) (G. Van Zyl et al., Can. J. Chem., 44, 2283 (1966)) in 500 ml of 96% ethanol, and the mixture was hydrogenated in a Parr hydrogenation apparatus for 7 h at 40 psi and room temperature in the presence of 1 g of 5% palladium on carbon. The catalyst was filtered off under nitrogen, and the filtrate was evaporated to dryness to give 4.89 g (100%) of 2,3-diaminobenzo[b]thiophene hydrochloride, which was used in the next step without further purification.

Aufarbeitung

  1. filtrationThe catalyst was filtered off under nitrogen
  2. customthe filtrate was evaporated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-0bac824f99ea43d8993245ed79641a4e
Quelldatensatz
uspto-grants-1993_01
Patentnummer
US05182279

Notizen zur Reaktion

Wird geladen…