1-(1H-indol-3-yl)-2-methylpropan-2-amine → [2-(1H-indol-3-yl)-1,1-dimethylethyl]{-[2-(2-methylprop-1-yloxy)phenoxy]ethyl}amine hydrochloride

HRID 1648399

Reaktionsgleichung

Reaktionsgleichung von HRID 1648399
CS(O[CH2:6][CH2:7][O:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[O:15][CH2:16][CH:17]([CH3:19])[CH3:18])(=O)=O.[Cl:20][C:21]1[CH:22]=[C:23]2[C:27](=[CH:28][CH:29]=1)[NH:26][CH:25]=[C:24]2[CH2:30][C:31]([NH2:34])([CH3:33])[CH3:32].N1C2C(=CC=CC=2)C(CC(N)(C)C)=C1>>[ClH:20].[NH:26]1[C:27]2[C:23](=[CH:22][CH:21]=[CH:29][CH:28]=2)[C:24]([CH2:30][C:31]([NH:34][CH2:6][CH2:7][O:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[O:15][CH2:16][CH:17]([CH3:18])[CH3:19])([CH3:32])[CH3:33])=[CH:25]1

Komponenten

4

Edukt 3

HCID 93531-(1H-indol-3-yl)-2-methylpropan-2-amineHCID 132605-Chloro-alpha,alpha-dimethyl-1H-indole-3-ethanamineHCID 152899972-[2-(2-Methylprop-1-yloxy)phenoxy]ethyl methanesulfonate

Produkt 1

HCID 19919953[2-(1H-indol-3-yl)-1,1-dimethylethyl]{-[2-(2-methylprop-1-yloxy)phenoxy]ethyl}amine hydrochloride

Versuchsvorschrift

Proceeding as an Example 3, but replacing 2-[2-(cyclopropylmethyloxy)phenoxy]ethyl methanesulfonate with 2-[2-(2-methylprop-1-yloxy)phenoxy]ethyl methanesulfonate and [2-(5-chloro-1H-indol-3-yl)-1,1-dimethylethyl]amine with [2- (1H-indol-3-yl)-1,1-dimethylethyl]amine, gave [2-(1H-indol-3-yl)-1,1-dimethylethyl]{-[2-(2-methylprop-1-yloxy)phenoxy]ethyl}amine hydrochloride, m.p. 147°-148° C.

Quellen und Nachweise

ORD-Eintrag
ord-82c864aed14a4276955dd18dbaccb624
Quelldatensatz
uspto-grants-1995_07
Patentnummer
US05436264

Verknüpfte Notizen

Wird geladen…