Propyl isocyanate → HCID 13228803, Verbindung

HRID 1648768Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1648768
[OH:1][NH:2][C:3]([CH:5]1[CH2:7][CH2:6]1)=[O:4].[CH2:8]([N:11]=[C:12]=[O:13])[CH2:9][CH3:10]>C(N(CC)CC)C.C(Cl)Cl>[CH2:8]([NH:11][C:12]([N:2]([O:1][C:12]([NH:11][CH2:8][CH2:9][CH3:10])=[O:13])[C:3]([CH:5]1[CH2:7][CH2:6]1)=[O:4])=[O:13])[CH2:9][CH3:10]

Komponenten

5

Edukt 2

HCID 61033Propyl isocyanateHCID 9989224N-hydroxycyclopropanecarboxamide

Produkt 1

HCID 13228803HCID 13228803, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 8471TriethylamineKatalysatorHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

N-hydroxycyclopropanecarboxamide (5.0 grams), n-propyl isocyanate (9.3 grams) and 5 drops of triethylamine were stirred at room temperature in about 100 ml of methylene chloride for about 12 hours. The reaction mixture was then concentrated leaving an oily residue which crystallized upon scratching. This solid was then recrystallized from a mixture of cyclohexane and isopropanol and dried. Upon drying, the desired N-((propylamino)carbonyl)-N-(((propylamino)carbonyl)-oxy)cyclopropanecarboxamide was obtained as a white solid, m.p. 76°-78° C.

Aufarbeitung

  1. concentrationThe reaction mixture was then concentrated
  2. customleaving an oily residue which
  3. customcrystallized
  4. customThis solid was then recrystallized from a mixture of cyclohexane and isopropanol
  5. customdried
  6. customUpon drying

Quellen und Nachweise

ORD-Eintrag
ord-852ccd5ecccd420cb879adc1a6e7f2c2
Quelldatensatz
uspto-grants-1983_11
Patentnummer
US04413009

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